Ototoxicity of Vistamycin

Objective Measures of Ototoxicity

A leading cause of preventable sensorineural hearing loss is therapeutic treatment with medications that are toxic to inner ear tissues, including certain drugs used to fight cancer and life-threatening infectious diseases. Ototoxic-induced hearing loss typically begins in the high frequencies and progresses to lower frequencies as drug administration continues (Campbell & Durrant, 1993; Campbe...

Ototoxicity of toluene in rats.

Toluene is a major industrial solvent and substance of abuse which is ototoxic in rats as shown by both behavioral testing and measurement of brainstem auditory evoked response (BAER) thresholds. The objective of this investigation was to examine the morphological (hair cell loss) and functional (BAER threshold elevations) changes resulting from toluene administration. In the preliminary experi...

Editorial: Cellular Mechanisms of Ototoxicity

Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States, National Center for Rehabilitative Auditory Research, VA Portland Health Care System, Portland, OR, United States, National Institute on Deafness and Other Communication Disorders, Bethesda, MD, United States, Hearing Center of Excellence, J-9, Defense Health Agency, Joint Base San Antonio, San Anto...

INF-α and Ototoxicity

INTRODUCTION INF- α is a common drug for the treatment of hepatitis B and C. Although a variety of related complications are discussed, possible ototoxic effects of this mediation are not well described. METHODS AND MATERIALS In a before-after control study, 24 patients who received INF- α for the treatment of hepatitis B and C and 30 normal controls were included. Subjective and objective ot...

Ototoxicity: Current Issues.